Compounded Budesonide + Mesalamine

Budesonide and mesalamine compounded enema is a customized medication used to treat inflammatory conditions of the lower gastrointestinal (GI) tract, particularly ulcerative colitis and proctosigmoiditis. This compounded enema combines two anti-inflammatory medications to provide targeted treatment to the rectum and distal colon.

Common Uses:
Ulcerative Colitis (UC) – Mild to Moderate
Reduces inflammation, swelling, and irritation in the rectum and sigmoid colon.
Helps patients who do not respond fully to oral medications alone.
Proctosigmoiditis
Treats inflammation of the rectum and sigmoid colon, often with fewer systemic side effects than oral steroids.
Crohn’s Disease (Rectal Involvement)
Used in localized Crohn’s disease affecting the rectum and lower colon.
How Does It Work?
Budesonide (Corticosteroid): A topical steroid that reduces inflammation and immune response in the gut with minimal systemic absorption, lowering the risk of side effects.
Mesalamine (5-ASA): A non-steroidal anti-inflammatory drug (NSAID) that targets intestinal inflammation, helping to maintain remission and reduce flare-ups.
Why Is It Compounded?
No Commercial Combination Product Available – While budesonide and mesalamine exist separately in oral and rectal forms, a combined enema formulation must be compounded for enhanced dual-action therapy.
Localized Therapy with Fewer Systemic Effects – The rectal enema form delivers medication directly to the inflamed areas, reducing the need for higher-dose oral steroids.
Customized Strengths – Dosages can be adjusted based on the patient’s condition and provider preference.
How Is It Used?
Typically administered once daily at bedtime, with the patient retaining the enema as long as possible (preferably overnight).
Patients should lie on their side or back during administration for better distribution.

Disclaimer: This information is for educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before using any compounded medication. Compounded medications are prepared based on a prescription from a licensed provider and may vary in strength, formulation, and use.